In this study carried out to a biological potent activity of a series 2-(3-methoxy-9H-carbazol-9-yl)-N-phenylacetamide analogous. These derivatives were synthesized from 2-(3-methoxy-9H-carbzol-9-yi) acetyl chloride treated aromatic primary amines in the presence of strong organic base such as triethylamine and MDC RT condition and the compound (4) also prepared by 3-methoxy-9H-Carbazole (3) with chloroacetylchloride in the presence of potassium carbonate in acetone as solvent at 40^oC. The intermediate (3) was obtained by 4-methoxy aniline treated with 1, 2-dichloro benzene in the presence of Pd(OAc)₂ in toluene as a solvent at 100^oC. The titled analogous can be evaluated by spectral tecniquich such as ¹HMNR, ¹³CNMR and LCMS. The structure of the desired compounds was determined by elemental analysis. In addition to, compounds were examined for in-vitro antimicrobial activity against bacterial strain and fungal strains.